Research

Precision CARRS

The CARRS Cohort is a state-of-the-art, population-based cohort of South Asians to address existing and emerging questions related to cardio-metabolic disease. Since its inception, the CARRS Cohort has grown to follow a diverse population-based sample of more than 20,000 adults living in India, with ongoing follow-up for clinical cardiovascular risk factors, clinical disease, and mortality. 

The Precision-CARRS study is a research collaboration between the Centre for Chronic Disease Control (CCDC), New Delhi, Rollins School of Public Health, Emory University, USA, All India Institute of Medical Sciences (AIIMS), New Delhi, Institute of Genomics and Integrative Biology (IGIB), New Delhi, Madras Diabetes Research Foundation (MDRF), Chennai, Sri Ramachandra of Higher Education and Research (SRM), Chennai, Ashoka University, Haryana and University of California, USA. 

The overarching goal of the five-year National Institutes of Health (NIH)-USA-funded Precision-CARRS study is to transform the traditional paradigm of cardiovascular disease (CVD) prevention/treatment to one of precision medicine and early-stage detection, to promote cardiovascular health for South Asians. 

PROJECT LEADS

Prof. Dorairaj Prabhakaran

Executive Director, Centre for Chronic Disease Control (CCDC)

Dr Sailesh Mohan

Deputy Director & Head-CVD Epidemiology, Centre for Chronic Disease Control

Dr Venkat Narayan

Emory University

Dr Arshed Ali Quyyumi

Emory University

Dr Nikhil Tandon

AIIMS

Dr Deepa Mohan

MDRF

Dr Ambuj Roy

AIIMS

Dr V. Mohan

MDRF

Dr Anurag Aggarwal

Ashoka University

Dr Shantanu Sengupta

CSIR - IGIB

PROJECT EXECUTION

The P-CARRS study started data collection in January 2023 with a target sample size of 14,000 in Delhi and Chennai. We have completed data collection in 1st round in around 14,300 participants and bio-samples collection in around 11,000 participants till date in both the sites.

The study comprises field activities which include in-person interviews, anthropometric and blood pressure measurements, bio-sample collection, and specialized imaging tests, which include cardiac echocardiography, carotid ultrasound, CT scan of the heart and liver, arterial stiffness, and electrocardiogram (ECG). Additionally, P-CARRS also focuses on integrative omics analyses, measurements of ambient air pollution, spousal and behavioral influences, and adverse cardiovascular events.

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IMPACT

The Precision-CARRS study will build on and enhance the scientific value of the ongoing CARRS Cohort study in Delhi and Chennai. This will help study the pathophysiologic, environmental, genomic, and socio-behavioral exposures on subclinical and clinical CVD phenotypes. This study fills deficiencies in knowledge regarding the evolution of CVD and its prediction in South Asian adults. These data will be informative for decision-makers and draw attention to important, burdensome, and disabling conditions in South Asia

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