The PURI-HF (Purifier Intervention in Heart Failure) project is a multi-site randomized controlled trial evaluating whether reducing household exposure to air pollution through the use of low-cost air purifiers can improve health outcomes among people living with heart failure with reduced ejection fraction (HFrEF). The project was initiated in response to growing evidence that exposure to ambient and household air pollution can adversely affect cardiovascular health, particularly among individuals who are already living with chronic heart and lung conditions. 

The project evaluates whether improving indoor air quality can translate into meaningful improvements in functional capacity, quality of life and healthcare outcomes. The primary outcome is the 6-minute walk test (6MWT), with secondary outcomes including health-related quality of life, hospitalizations, mortality, sleep, BP, and cost-effectiveness. The project also incorporates continuous environmental monitoring and digital health technologies to better understand participants’ exposure and engagement. 

The target beneficiaries are individuals living with HFrEF, particularly those residing in areas with high levels of air pollution. The project aims to generate evidence that can inform affordable, scalable approaches to reducing pollution exposure as part of cardiovascular disease management in India. The study is jointly funded by NIEHS and ICMR.