This project was initiated through COALESCE program with collaboration between Emory University, Atlanta, Georgia, USA, Tata Memorial Hospital, Mumbai, India and the Centre for Chronic Disease Control, New Delhi, India. COALESCE (2020-2024) was co-designed by collaborators at Emory University (USA), the Centre for Chronic Disease Control (India), and Addis Ababa University (Ethiopia) to enhance capacity for research and action for chronic diseases in India and Ethiopia. The primary aim of this work was to utilize real-world clinical data of hospitalized patients such as from the electronic medical records and hospital-based cancer registries to investigate the survival patterns of oral cavity and oropharyngeal cancers in India and in the USA. We aimed to apply exposome framework (i.e., integration of multiple exposure factors over time to understand the combined impact on biology and health outcomes), to elucidate reasons for the similarities or differences in survival patterns between the selected geographical regions. Oral cavity and oropharyngeal cancers are highly fatal globally but reveal certain geographical differences in survival, for example India records relatively low survival compared to the USA.